Rias Ali, MD, FACC — Patient Education

Heart Failure

TZDs and Heart Failure (Pioglitazone)

TZD diabetes pills (pioglitazone) and heart failure: why they cause fluid retention, who should avoid them, and safer alternatives for your heart.

This is a free, plain-language patient education guide written by Rias Ali, MD, FACC, a board-certified interventional cardiologist. Every guide is grounded in current peer-reviewed evidence and major society guidelines, organized in a way patients can actually use during a visit.

Download the TZDs and Heart Failure (Pioglitazone) guide

PDF · 1012 KB · Updated August 2026

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What's inside this guide

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